How does fosfomycin work?

Fosfomycin is a broad-spectrum antibiotic that works by inhibiting bacterial cell wall synthesis. Specifically, it targets an enzyme called MurA (UDP-N-acetylglucosamine enolpyruvyl transferase), which is essential for the first step in the formation of the bacterial cell wall. By blocking this enzyme, fosfomycin prevents the bacteria from constructing a vital component of their cell wall, leading to cell lysis and death. This mechanism makes fosfomycin effective against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable treatment option for urinary tract infections (UTIs) and other bacterial infections. Its unique mode of action also helps in reducing the risk of cross-resistance with other antibiotics.
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